A New Synthetic Method for Pyrimidine Nucleoside
نویسندگان
چکیده
منابع مشابه
Antileukemic effects of pseudoisocytidine, a new synthetic pyrimidine C-nucleoside.
Pseudoisocytidine, a new synthetic pyrimidine C-nucleoside, which might be considered a more stable analog of 5-azacytidine, is active in vitro and in vivo, i.p. and p.o., against various 1-beta-D-arabinofuranosylcytosine-resistant lines of mouse leukemia. This antileukemic activity is blocked by cytidine but not by deoxycytidine or thymidine.
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Novel synthetic approach to mono-O-protected anti-conformationally constrained pyrimidine acyclic nucleoside was attained from the coupling of lithiated 2,4-dimethoxy-6-methylpyrimidine with 1-benzyloxy-3-(tert-butyldiphenylsilyloxy)propan-2-one, followed by the sequential reactions of methylthiomethylation, cyclization, hydroxylation, and dealkylation.
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The WHO has declared tuberculosis (TB) a global health emergency. Therefore, there is an urgent need to discover and develop new anti-TB drugs. Here we report on a new category of 5-substituted pyrimidine nucleosides as potent inhibitors of Myco-bacterium tuberculosis growth in vitro. A series of 2'-deoxy-, 3'-azido-2',3'-dideoxy-, and 3'-amino-2',3'-dideoxypyrimidine nucleoside analogues beari...
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The field of nucleosides has undergone rapid growth and development during the past decade'—3. Whereas, earlier studies were concerned with the development of methods for the synthesis of the nucleoside components of the nucleic acids, today several methods are available—each of which has its advantages and limitations. The host of "fraudulent" or "anomalous" nucleosides available today attests...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1961
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.9.249